As US ties fray, Netanyahu's claim to unrivalled influence in Washington is under growing scrutiny.
Oval Office meeting on Tuesday is first since US-Israel launched unpopular war with Iran.
The Israeli PM's visit to the US comes amid raids in the occupied West Bank, before the October 27 elections.
The meeting comes amid signs of friction between the two leaders and decreasing public support for Israel in the US.
Recent attacks on international journalists and a US congressman have once again put a spotlight on settler violence.
With relations between Israel and the US fraught, some are speculating whether the special relationship may be at an end
The visit would mark Netanyahu's seventh visit to the US since Trump returned to office for a second term as president.
The US and Israel have signed a deal allocating land for a permanent US embassy in West Jerusalem.